System: Genitourinary: Bladder: Neoplastic: Adenocarcinoma, Lobular Type
System: Genitourinary: Bladder: Neoplastic: Adenocarcinoma, Lobular Type
normal epithelium with underlying stroma containing scattered enlarged single cells Image
more densely populated tumor area shows single filing resembling lobular carcinoma of breast. While metastatic involvement of the bladder can be seen in up to 3.3% of breast carcinomas, this very rarely manifests with urological symptoms and almost always form part of widespread disseminated disease. Image
keratin stain highlights diffusely invasive growth pattern with single-cell infiltration and areas showing a linear single-cell filing pattern or solid sheets of discohesive cells Image
This subtype of TCC shows loss of e-cadherin in up to 70% of cases vs 10% in other TCC types, in somes series (Baldwin). Reduced expression of E-cadherin in bladder cancer has been associated with high stage and grade and with a poor prognosis (Popov).
• Bladder : Adenocarcinoma, Signet Ring Type
Baldwin L, Lee AH, Al-Talib RK, Theaker JM. Transitional cell carcinoma of the bladder mimicking lobular carcinoma of the breast: a discohesive variant of urothelial carcinoma. Histopathology. 2005 Jan;46(1):50-6.
Popov Z, Gil-Diez de Medina S, Lefrere-Belda MA et al. Low E-cadherin expression in bladder cancer at the transcriptional and protein level provides prognostic information. Br. J. Cancer 2000; 83; 209–214
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