plump myoid cells in broad bundles Image

variation in cellularity with lighter staining area to the left; due to hyalinization Image

more cellular area with polygonal cells with slightly hyperchromatic nuclei Image

bundles seen, may raise the ddx of nodular fasciitis Image

irregular shaped vessel is typical; note some lymphocytes in background Image

hemangiopericytoma like vessels are typical Image

Myofibromas and myofibromatosis are a group of lesions originally thought to be congenital, but have now been described in all ages.

They can be single lesions (solitary myofibroma) or multiple (myofibromatosis). Regardless of their centricity and the age of the patient, these lesions tend to favor the head and neck region. In a study of 79 myofibromas/myofibromatosis conducted by Foss and colleagues in 2000, the mean age was 26 years. The most frequently affected site was the mandle, followed by tongue, lips and buccal area. 1/3 of the tumors affected the bones of the jaws, about half of these tumors were intramedullary (intraosseous), and all of these patients were younger than 18.