System: Gynecological: Endometrium: Neoplastic: Endometrioid Adenocarcinoma Co-existing with Ovarian Adenocarcinoma
System: Gynecological: Endometrium: Neoplastic: Endometrioid Adenocarcinoma Co-existing with Ovarian Adenocarcinoma
case 1 - endometrial ca suh09-14210 Image
case 1 another uterine photo Image
case 1 - photo from ovary Image
ovary on left / endometrium on right same magnification Image
Synchronous primary cancers of the endometrium and ovary are found in 10% of those with ovarian cancer and 5% of endometrial cancer (Soliman). One study suggests that beta-catenin expression pattern, beta-catenin mutations, and MI, together with clinicopathologic findings, could aid in distinguishing between the metastatic or independent origin of simultaneous endometrioid ovarian and endometrial carcinomas (morena-Bueno).
The median age is around 50 years in women with synchronous primary cancers of the endometrium and ovary. In contrast, women who develop endometrial or ovarian cancer alone are predominantly postmenopausal and in the sixth or seventh decade of life (median age of onset of 60 and 63 years, respectively. Associated with obesity, premenopausal status, and nulliparity
patients with synchronous primary cancers have an excellent overall prognosis with survival approaching 10 years in certain subgroups.
• Ovary : Transitional Cell Carcinoma
Chiang YC, Chen CA, Huang CY, Hsieh CY, Cheng WF. Synchronous primary cancers of the endometrium and ovary.Int J Gynecol Cancer. 2008 Jan-Feb;18(1):159-64.
Soliman PT, Slomovitz BM, Broaddus RR, Sun CC, Oh JC, Eifel PJ, Gershenson DM, Lu KH. Synchronous primary cancers of the endometrium and ovary: a single institution review of 84 cases. Gynecol Oncol. 2004 Aug;94(2):456-62.
Moreno-Bueno G, Gamallo C, Pérez-Gallego L, de Mora JC, Suárez A, Palacios J. beta-Catenin expression pattern, beta-catenin gene mutations, and microsatellite instability in endometrioid ovarian carcinomas and synchronous endometrial carcinomas. Diagn Mol Pathol. 2001 Jun;10(2):116-22.
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