The characteristic lesion is that of a cystic cluster of yeast with no well-defined inflammatory response, cases that involve the brain usually also involve the meninges. Image

pseudocysts with the yeast organisms in them has polysaccharide capsule around it htat is prominent Image

The lack of identifiable endotoxins or exotoxins may account for the absence of extensive necrosis early in cryptococcal infections. Cerebral damage is largely due to tissue distortion secondary to the expanding fungal burden. Extensive inflammation is rare. Image

affects those with immune system deficiencies such as AIDS. spread by bird droppings; over 50 serotypes, most human infection involve C neoformans or C gatti.

Meningitis and meningoencephalitis are usually subacute or chronic in nature. Presentating complaints include headache, nausea, vomiting, altered mental status and / or lethargy.

Amphotericin B, which has substantially improved the mortality related to this disaese.