Liver shows hepatomegaly and these pale cells with wispy cytoplasm. This patient has a markedly elevated BMI and is insulin dependent. Note the nuclear glycogenation. Image

Eosinophilic dot in the cytoplasm may represent a giant mitochondria Image

PAS stain is strongly and diffusly positive Image

The cytoplasmic material is no longer present on PAS-diastase compatible with glycogen. Image