System: Breast: Invasive Carcinoma - Special Types: Neoplastic: Granular cell tumor
System: Breast: Invasive Carcinoma - Special Types: Neoplastic: Granular cell tumor
Breast lobules to the right. GCT on the left. Image
Biopsy. Ink on the top and bottom. Nice area of breast lobule and GCT on the right. Image
Granular cells with their foamy flocculent cytoplasm can be appreciated here. Quite a pretty tumor actually.
S-100 is strikingly strong.
Granular cell tumor is a rare benign neoplasm of the breast, but important to recognize as it can mimic invasive malignant tumor. Granular cell tumors are thought to be derived from Schwann cells (hence S-100 positive) and can arise from any part of the body. Most are seen in the head and neck, but approximately 5-8% arise in the breast (Montagnese).
Adeniran A, et al. Granular cell tumor of the breast: a series of 17 cases and review of the literature. Breast J. 2004 Nov-Dec;10(6):528-31.
Montagnese MD, et al. Granular cell tumor of the breast. Am Surg. 2004 Jan;70(1):52-4.
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